Consolidating Ltp Translation And Ch.5 Complete Test Bank 3e - Neurobiology Learning 3e | Test Bank Rudy by Jerry W. Rudy. DOCX document preview.
Chapter 5: Consolidating LTP: Translation and Transcription
Test Bank
Type: true-false
Title: Chapter 5 - Question 1
1. According to the de novo protein synthesis (DNPS) hypothesis, long-lasting memories require that the learning experience generate new proteins.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 2
2. The consolidating event is likely the building of an enlarged, stable actin cytoskeleton.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 3
3. Anisomycin causes LTP produced by intense, high-frequency stimulation to resemble LPT produced by a weak-induction stimulus.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 4
4. The fact that anisomycin has no effect on short-lasting LTP implies that it requires new protein to be generated.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 5
5. Transcription refers to the creation of new protein.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 6
6. Both transcription and translation depend on post-translation modifications of existing protein.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 7
7. Local protein synthesis depends on already existing mRNA.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 8
8. CREB is an important translation factor found in dendrites.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 9
9. To produce mRNA, signaling molecules enter the nucleus to phosphorylate transcription factors.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 10
10. Dendritic protein synthesis (local protein synthesis) is not sufficient to produce relatively long-lasting LTP.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 11
11. Genomic signaling refers to processes initiated by synaptic events that lead to the transcription of new mRNA.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 12
12. Synapse-to-nucleus signaling depends on voltage-gated calcium channels, but soma-to-nucleus signaling does not.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 13
13. The first of the two waves of protein synthesis depends on genomic signaling.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 14
14. Extracellular calcium is derived from the endoplasmic reticulum.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 15
15. NMDA receptors and voltage-gated calcium channels allow extracellular calcium to enter the neuron.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 16
16. Calcium-induced calcium release refers to extracellular calcium entering the cell.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 17
17. Calcium-induced calcium release occurs when calcium entering via NMDA receptors binds to RyRs on the endoplasmic reticulum.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 18
18. If the IP3 receptor is antagonized, a short lasting LTP1 can still be produced.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 19
19. Metabotropic glutamate receptors have ion channels.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 20
20. Antidromic stimulation can convert a short-lasting LTP produced by a weak induction into a long-lasting LTP.
a. True
b. False
Type: true-false
Title: Chapter 5 - Question 21
21. In the soma-to-nucleus cascade, repetitive action potentials are assumed to open voltage-dependent calcium channels.
a. True
b. False
Type: essay/short answer question
Title: Chapter 5 - Question 22
22. What two general processes are necessary for memory consolidation?
Type: essay/short answer question
Title: Chapter 5 - Question 23
23. Describe the de novo protein synthesis hypothesis.
Type: essay/short answer question
Title: Chapter 5 - Question 24
24. Why has anisomycin been used to study LTP?
Type: essay/short answer question
Title: Chapter 5 - Question 25
25. Describe the influence of the protein synthesis inhibitor anisomycin on LTP.
Type: essay/short answer question
Title: Chapter 5 - Question 26
26. A strong stimulus initiates what two rounds of protein synthesis?
Type: essay/short answer question
Title: Chapter 5 - Question 27
27. Where is mRNA found in the neuron?
Type: essay/short answer question
Title: Chapter 5 - Question 28
28. Why does separating the dendrites from the soma provide evidence for local protein synthesis?
Type: essay/short answer question
Title: Chapter 5 - Question 29
29. Why is emetine important?
Type: essay/short answer question
Title: Chapter 5 - Question 30
30. What two major findings illustrate the important role local protein synthesis plays in L-LTP?
Type: essay/short answer question
Title: Chapter 5 - Question 31
31. What is a major feature of the genomic signaling hypothesis?
Type: essay/short answer question
Title: Chapter 5 - Question 32
32. What are plasticity products (PPs)?
Type: essay/short answer question
Title: Chapter 5 - Question 33
33. Describe the order of events in the synapse-to-nucleus signaling model.
Type: essay/short answer question
Title: Chapter 5 - Question 34
34. What is the major assumption in the soma-to-nucleus signaling model?
Type: essay/short answer question
Title: Chapter 5 - Question 35
35. Provide experimental support for the soma-to-nucleus model.
Type: essay/short answer question
Title: Chapter 5 - Question 36
36. Give two reasons why the ER is important in the context of synaptic plasticity.
Type: essay/short answer question
Title: Chapter 5 - Question 37
37. What are the calcium sources important for LTP?
Type: essay/short answer question
Title: Chapter 5 - Question 38
38. What were the results when the protein synthesis inhibitor emetine was applied to the entire hippocampal slice and when it was applied to only the soma?
Type: essay/short answer question
Title: Chapter 5 - Question 39
39. What is calcium-induced calcium release (CICR)?
Type: essay/short answer question
Title: Chapter 5 - Question 40
40. Name the two receptors that can release calcium from the ER into the dendritic compartment. What do they bind to?
Type: essay/short answer question
Title: Chapter 5 - Question 41
41. Activating four sources can increase calcium levels. What are these sources?
Type: essay/short answer question
Title: Chapter 5 - Question 42
42. Why is the activation of CREB a post-translation modification?
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