Maintaining Long-Term Potentiation Chapter 7 Test Bank - Neurobiology Learning 3e | Test Bank Rudy by Jerry W. Rudy. DOCX document preview.
Chapter 7: Maintaining Long-Term Potentiation
Test Bank
Type: true-false
Title: Chapter 7 - Question 1
1. Memories outlast the molecules that support the initial synaptic changes.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 2
2. According to Crick, even though memory molecules decay they can be replaced one at a time so that the existing structure can survive.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 3
3. Interfering with a memory maintenance molecule 24 hours after the memory is formed should have no effect on the ability to retrieve the memory.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 4
4. CaMKII does not have self-perpetuating properties.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 5
5. Even though CaMKII has self-perpetuating properties, this kinase does not appear to be a memory maintenance molecule.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 6
6. A combination of many molecules is required to translate of PKMζ.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 7
7. Potentiated synapses endure because there is no pressure to return to their basal unpotentiated state.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 8
8. PKMζ is perpetually active and it self-perpetuates.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 9
9. ZIP application prior to induction will prevent late-phase LTP but not initial LTP expression.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 10
10. PKMζ lacks an inhibitory unit, so it is always inactive.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 11
11. PKMζ lacks an inhibitory unit, so it is always active.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 12
12. ZIP is used to inactivate PKMζ.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 13
13. PKMζ is the only “memory maintenance” molecule.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 14
14. The fact that ZIP is nonselective in eliminated LTP suggests that there may be more than one maintenance kinase.
a. True
b. False
Type: true-false
Title: Chapter 7 - Question 15
15. A crucial experiment by Sacktor’s group (Tsokas et al., 2016) revealed that antisense to PKMζ erased LTP in both the wildtype and the PKCι/λ mutant mouse.
a. True
b. False
Type: essay/short answer question
Title: Chapter 7 - Question 16
16. What two forces operate to return synapses to their basal unpotentiated state?
Type: essay/short answer question
Title: Chapter 7 - Question 17
17. What is the molecular turnover problem?
Type: essay/short answer question
Title: Chapter 7 - Question 18
18. What was Crick’s solution to the molecular turnover problem?
Type: essay/short answer question
Title: Chapter 7 - Question 19
19. What was Mary Kennedy’s view of “memory maintenance molecules”?
Type: essay/short answer question
Title: Chapter 7 - Question 20
20. How is PKMζ different from PKC?
Type: essay/short answer question
Title: Chapter 7 - Question 21
21. Name the molecules necessary for the initial translation of PKMζ.
Type: essay/short answer question
Title: Chapter 7 - Question 22
22. Where is PKMζ mRNA found and translated?
Type: essay/short answer question
Title: Chapter 7 - Question 23
23. Explain how PKMζ self-perpetuates.
Type: essay/short answer question
Title: Chapter 7 - Question 24
24. What is ZIP’s function?
Type: essay/short answer question
Title: Chapter 7 - Question 25
25. Does ZIP applied two- or five-hours following induction have any effects on LTP expression?
Type: essay/short answer question
Title: Chapter 7 - Question 26
26. At the synaptic level, how does ZIP reverse LTP maintenance?
Type: essay/short answer question
Title: Chapter 7 - Question 27
27. Describe the two general ways in which PKMζ maintains potentiation.
Type: essay/short answer question
Title: Chapter 7 - Question 28
28. Use the following words to describe the endocytosis of GluA2 receptors in a few sentences: Trk, GluA2, endocytic zone, PSD, activation, NSF–PICK1 complex.
Type: essay/short answer question
Title: Chapter 7 - Question 29
29. Where is PKMζ translated?
Type: essay/short answer question
Title: Chapter 7 - Question 30
30. If the gene for PKMζ is deleted LTP will not be maintained.
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