Consolidating Ltp Specific Mechanisms Exam Prep Chapter 6 3e - Neurobiology Learning 3e | Test Bank Rudy by Jerry W. Rudy. DOCX document preview.
Chapter 6: Consolidating LTP: Specific Mechanisms
Test Bank
Type: true-false
Title: Chapter 6 - Question 1
1. Local protein synthesis can provide protein in the right places on demand.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 2
2. Local protein synthesis occurs before mRNA is delivered to the dendritic spine region.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 3
3. Microtubules are an essential component of mRNA delivery to the dendritic spine region.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 4
4. mRNA in the dendritic spine region are stationary.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 5
5. Inhibiting actin polymerization has no effect on the capture of mRNA by spines.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 6
6. The induction of LTP is accompanied by local movement of polyribosomes into the spine.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 7
7. Local protein synthesis requires the assembly of TOP proteins into functional ribosomal complexes.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 8
8. Proteasomes tag proteins for degradation.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 9
9. Ubiquitin tags proteins for degradation.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 10
10. The mTOR–TOP pathway is critical for the induction of LTP.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 11
11. BDNF is synthesized, stored, and released from the presynaptic neuron, but it can also be released from dendrites.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 12
12. Inhibiting the UPS system inhibits LTP induction and prevents the late enduring phase of LTP.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 13
13. The antisense methodology allows researchers to directly prevent transcription.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 14
14. The antisense methodology allows researchers to prevent the translation of specific mRNA into protein
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 15
15. The application of BDNF can produce long-lasting LTP even if the translation of Arc is prevented by antisense.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 16
16. One advantage of clustered synapses is that it is easier for the glutamate release to depolarize the neuron.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 17
17. Clustered spines can capture protein synthesized in their vicinity.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 18
18. The synaptic tag and capture hypothesis was proposed to explain how plasticity products (mRNA and protein) get targeted to the correct synapses.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 19
19. Only untagged synapses can capture plasticity products produced by a strong stimulus.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 20
20. All tagged synapses participate in the generation of new plasticity products.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 21
21. Blocking protein synthesis has no effect on mRNA distribution produced by glutamate release onto a spine.
a. True
b. False
Type: true-false
Title: Chapter 6 - Question 22
22. Stimulated spines have fewer polyribosomes than unstimulated spine.
a. True
b. False
Type: essay/short answer question
Title: Chapter 6 - Question 23
23. What is the general advantage of local protein synthesis?
Type: essay/short answer question
Title: Chapter 6 - Question 24
24. Discuss the significance of the concept of the protein-on-demand system in relation to the classic central dogma view.
Type: essay/short answer question
Title: Chapter 6 - Question 25
25. Briefly describe the role of microtubules.
Type: essay/short answer question
Title: Chapter 6 - Question 26
26. What are primary steps to the initiation of local protein synthesis?
Type: essay/short answer question
Title: Chapter 6 - Question 27
27. What are TOP mRNAs? Explain how they enhance translation capacity?
Type: essay/short answer question
Title: Chapter 6 - Question 28
28. What are the sources of BDNF?
Type: essay/short answer question
Title: Chapter 6 - Question 29
29. What is an immediate early gene?
Type: essay/short answer question
Title: Chapter 6 - Question 30
30. What is an antisense oligonucleotide? How is it used to study LTP?
Type: essay/short answer question
Title: Chapter 6 - Question 31
31. The synaptic tag and capture hypothesis is based on three assumptions. What are they?
Type: essay/short answer question
Title: Chapter 6 - Question 32
32. Explain how a weak stimulation can produce L-LTP?
Type: essay/short answer question
Title: Chapter 6 - Question 33
33. How does the UPS work?
Type: essay/short answer question
Title: Chapter 6 - Question 34
34. What is ubiquitination?
Type: essay/short answer question
Title: Chapter 6 - Question 35
35. How does the UPS contribute to protein synthesis and consolidation?
Type: essay/short answer question
Title: Chapter 6 - Question 36
36. What is the relationship between transcription repressor proteins, the UPS system, and enduring LTP?
Type: essay/short answer question
Title: Chapter 6 - Question 37
37. What is rapamycin?
Type: essay/short answer question
Title: Chapter 6 - Question 38
38. What is the basic signal cascade that produces local protein synthesis?
Type: essay/short answer question
Title: Chapter 6 - Question 39
39. What is the critical contribution of the mTOR complex in local protein synthesis?
Type: essay/short answer question
Title: Chapter 6 - Question 40
40. What are some advantages of LTP being induced in clusters of spines?
Type: essay/short answer question
Title: Chapter 6 - Question 41
41. What is the function of a synaptic tag and what is its physical basis?