Ch.8 | Test Bank + Answers – The Normochromic Anemias Due to - Test Bank | Hematology in Practice 3e by Betty Ciesla by Betty Ciesla. DOCX document preview.
Chapter 8. The Normochromic Anemias Due to Hemoglobinopathies
Multiple Choice
1. The hemoglobin variant that is seen frequently in the Southeast Asian population and migrates with Hgb C at pH 8.6 is:
A. Bart’s
B. F
C. E
D. H
L.O. 8.9 & 8.12
2. A blood smear from a patient with sickle cell crisis shows 80 nucleated red blood cells per 100 leukocytes. The total leukocyte count is 18 × 109/L. The corrected white blood cell count is:
A. 17,200
B. 9,000
C. 10,000
D. 13,400
L.O. 8.14
3. A patient with sickle cell anemia may develop cardiopulmonary disease due to:
A. Untreated leg ulcers
B. High blood viscosity
C. Increased Hgb F levels
D. Hemolytic crisis
L.O. 8.6, 8.7, & 8.2
4. Autosplenectomy is characteristic of:
A. Sickle cell trait
B. Hgb C disease
C. Thalassemia
D. Sickle cell anemia
L.O. 8.5, 8.6, & 8.7
6. When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _________ crisis has occurred.
A. aplastic
B. hemolytic
C. vaso-occlusive
D. cardiac
L.O. 8.5, 8.6, & 8.7
7. Mr. Bennett was admitted with a hematocrit of 28%. He has a history of chronic anemia, moderate splenomegaly, and recent retinal hemorrhages. His peripheral smear reveals target cells, and some show structures jutting from the red blood cell membrane. The most probable diagnosis is:
A. Hgb S-S
B. Hgb A-C
C. Hgb S-C
D. Hgb A-A
L.O. 8.5
8. Sickle cell disease is best differentiated from sickle cell trait by:
A. Wright smear examination
B. Determination of fetal hemoglobin
C. Genetic testing
D. Hemoglobin electrophoresis
L.O. 8.5
9. Which of the following “poikilocytes” are classically associated with hemoglobinopathies and liver disease?
A. Spherocytes
B. Sickle cells
C. Acanthocytes
D. Target cells
L.O. 8.1
10. A male with sickle cell trait and a female sickle cell trait have what likelihood of having a child with sickle cell anemia?
A. 10%
B. 25%
C. 50%
D. 100%
L.O. 8.4 & 8.10
11. Painful swelling of hands and feet caused by sickle cells in the microcirculation of infants is termed:
A. Dactylitis
B. Necrosis
C. Apoptosis
D. Fibrosis
L.O. 8.5 & 8.7
12. In patients with sickle cell trait and no complicating disease:
A. NRBCs and polychromasia are usually seen on the peripheral smear
B. Sickle cells are prevalent in the peripheral blood
C. There may be occasional hematuria
D. There is a severe decrease in Hgb, Hct, and RBC count
L.O. 8.5 & 8.11
13. The hemoglobin that cannot be separated from Hgb S through electrophoresis in buffer at pH 8.6 is:
A. Hgb D
B. Hgb C
C. Hgb A
D. Hgb F
L.O. 8.8 & 8.9
14. The lungs are particularly susceptible in individuals with sickle cell disease and may be susceptible to:
A. COPD
B. Pulmonary hypertension
C. Aplastic crisis
D. Cardiac crisis
L.O. 8.7
15. A 26-year-old day laborer with a long history of anemia has a several months’ history of dyspnea, fever, and pulmonary pain. Additionally, he complains of tightness in the chest and upper abdominal region. His hematology values are as follows:
WBC 15.9 × 109/L
RBC 2.9 × 1012/L
Hgb 9.5 g/dL
Hct 30%
MCV 103 fL
MCH 31 pg
MCHC 32%
NRBC 15/100 WBC
Platelets 275 × 109/L
Reticulocytes 16.8%
The hemoglobin electrophoresis results are as follows:
Hgb A =3%
Hgb A2 = 2%
Hgb S = 85%
Hgb F = 10%
The most likely diagnosis is:
A. Sickle cell trait
B. Sickle cell disease
C. Beta thalassemia minor
D. Sickle thalassemia
L.O. 8.5, 8.6, & 8.9
16. In sickle cell anemia, _____is substituted for glutamine.
A. valine
B. lysine
C. adenine
D. leucine
L.O. 8.3
17. Patients with sickle cell anemia generally have a hemoglobin value between:
A. 2 and 4 g/dL
B. 6 and 8 g/dL
C. 8 and 10 g/dL
D. 10 and 12 g/dL
L.O. 8.5
18. In hemoglobin C disease, ____ is substituted for glutamic acid.
A. valine
B. adenine
C. lysine
D. leucine
L.O. 8.3
19. Alkaline electrophoresis will not separate hemoglobin C from:
A. Hemoglobin A2
B. Hemoglobin F
C. Hemoglobin S
D. Hemoglobin A
L.O. 8.8 & 8.9
20. In hemoglobin C disease, the majority of the red blood cells appear as:
A. Target cells
B. Spherocytes
C. Elliptocytes
D. “Bars of gold”
L.O. 8.5
21. ____ is the second most common hemoglobin variant worldwide.
A. Hemoglobin S
B. Hemoglobin E
C. Hemoglobin C
D. Hemoglobin D
L.O. 8.12
22. Which of the following hemoglobins contain an alpha chain variant?
A. Hemoglobin C
B. Hemoglobin G
C. Hemoglobin S
D. Hemoglobin A2
L.O. 8.12
23. The clinical picture of a patient with Hgb S–beta-thalassemia is similar to that seen in which other hemoglobinopathy?
A. Sickle cell anemia
B. Sickle cell trait
C. Hgb C disease
D. Hgb E disease
L.O. 8.13
24. The principle behind hemoglobin electrophoresis is best represented by which of the following statements?
A. Normal hemoglobin does not precipitate in high-molarity buffered phosphate solutions.
B. Hemoglobins migrate to different locations depending on time, pH, and media used.
C. In a pH range of 3 to 10, hemoglobins achieve their isoelectric point.
D. Hematology analyzers count nucleated red blood cells as white blood cells.
L.O. 8.15
NARRBEGIN:
NARREND
25. The cell at the tip of the pointer would be described as a(n):
A. Acanthocyte
B. Elliptocyte
C. Sickle cell
D. Stomatocyte
NAR: Figure 8-2
L.O. 8.5
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Test Bank | Hematology in Practice 3e by Betty Ciesla
By Betty Ciesla