Full Test Bank Chapter 7 Normochromic Anemia Disorders

Chapter 7. Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

Multiple Choice

1. Spherocytes do not function well in the splenic environment because the:

A. Osmotic environment of the spherocyte is impaired

B. Immunologic function of the spleen is impaired

C. Reservoir function is impaired

D. Filtration function of the spleen is compromised

L.O. 7.1

2. Cholelithiasis is a frequent complication of patients with hereditary spherocytosis because:

A. Spherocytes are an abnormal red blood cell morphology

B. The gallbladder does not function well in this condition

C. Continued hemolysis in this condition causes gallstones to form

D. The filtration function of the spleen is overworked

L.O. 7.3

3. Spherocytes differ from normal cells in all of the following ways except having:

A. Decreased surface-to-volume ratio

B. Decreased central pallor

C. Decreased resistance to hypotonic saline

D. Increased deformability

L.O. 7.2

4. The RBC inclusions that are composed of denatured hemoglobin are called:

A. Pappenheimer bodies

B. Howell-Jolly bodies

C. Heinz bodies

D. Siderotic granules

L.O. 7.10

5. Red blood cells that are rigid, provide resistance to malaria, and are spoon shaped are termed:

A. Burr cells from kidney disease

B. Spherocytes from hereditary spherocytes

C. Ovalocytes from Southeast Asian ovalocytosis

D. Sickle cells from sickle cell disease

L.O. 7.11

6. Spherocytes may enter the circulation via a variety of mechanisms. To distinguish the CBC of a patient with hereditary spherocytosis from the CBC of a patient with autoimmune hemolytic anemia, one could use the:

A. MCHC

B. Hematocrit

C. MCH

D. MCV

L.O. 7.3

7. One of the least severe clinical manifestations of G6PD deficiency is:

A. Acute hemolytic anemia

B. Favism

C. Neonatal jaundice

D. Congenital non-spherocytic hemolytic anemia

L.O. 7.8 & 7.9

8. An anemia that manifests as decreased marrow cellularity, pancytopenia, and a reticulocytopenia is appropriately termed:

A. Megaloblastic anemia

B. Aplastic anemia

C. Sideroblastic anemia

D. Iron deficiency anemia

L.O. 7.12

9. Individuals with Fanconi’s anemia characteristically will have:

A. Intravascular hemolysis

B. Increased Hgb F

C. Ringed sideroblastics

D. Thrombocytosis

L.O. 7.12

10. An osmotic fragility test is performed on a patient’s sample. Initial hemolysis occurs at 0.75% NaCl and complete hemolysis occurs at 0.50% NaCl. These results are indicative of which of the following disorders?

A. Sickle cell anemia

B. Hgb C disease

C. Thalassemia major

D. Hereditary spherocytosis

L.O. 7.5

11. Which of the following is most closely associated with G6PD deficiency?

A. Continuous intravascular hemolysis occurs.

B. G6PD deficiency is a sex-linked inherited disease.

C. Splenectomy is commonly done to control symptoms.

D. The majority of the erythrocytes in these individuals are microcytic.

L.O. 7.9

12. In hereditary spherocytosis, the reticulocyte count will typically be:

A. Less than 0.5%

B. 0.5% to 1.5%

C. 3% to 10%

D. Greater than 10%

L.O. 7.3

13. The deficit of which of these is most closely associated with Southeast Asian ovalocytosis?

A. Spectrin

B. Ankyrin

C. Molecular band 3

D. G6PD

L.O. 7.11

14. Bite cells are formed from:

A. The spleen “pitting” out Heinz bodies

B. Third-degree burns

C. Spectrin deficiency

D. G6PD deficiency

L.O. 7.10

15. The inability of the red blood cell to generate ATP for membrane function is most closely associated with:

A. Pyruvate kinase deficiency

B. G6PD deficiency

C. Fanconi’s anemia

D. Congenital hemolytic anemia

L.O. 7.8

16. Which of the following red blood cell membrane defects results in an increased sensitivity to complement lysis?

A. Cold agglutinin syndrome

B. Paroxysmal nocturnal hemoglobinemia

C. Diamond Blackfan anemia

D. Hereditary spherocytosis

L.O. 7.8

17. An eccentric “puddling” of a red blood cell’s hemoglobin contents is most closely associated with:

A. Stomatocytosis

B. Xerocytosis

C. G6PD deficiency

D. Pyruvate kinase deficiency

L.O. 7.11

NARRBEGIN:

NARREND

18. The cell at the tip of the pointer is seen in which of the following conditions?

A. G6PD deficiency

B. Hereditary stomatocytosis

C. Hereditary elliptocytosis

D. Hereditary spherocytosis

NAR: Figure 7-1

L.O. 7.4 & 7.7

NARRBEGIN:

NARREND

19. The cell at the tip of the pointer is referred to as which of the following?

A. Acanthocyte

B. Bite cells

C. Spherocyte

D. Stomatocyte

NAR: Figure 7-7

L.O. 7.10

NARRBEGIN:

NARREND

19. The inclusions pictured here are seen with supravital staining only. These inclusions are most likely:

A. Heinz bodies

B. Howell-Jolly bodies

C. Pappenheimer bodies

D. Due to stain contamination

NAR: Figure 7-8

L.O. 7.10

True/False

20. A defect in stomatin is the main cause of hereditary spherocytosis.

L.O. 7.6