Ciesla The Macrocytic Anemias Test Bank Chapter 6 - Test Bank | Hematology in Practice 3e by Betty Ciesla by Betty Ciesla. DOCX document preview.
Chapter 6. The Macrocytic Anemias
Multiple Choice
1. Which of the following terms describes the appearance of the erythropoietic precursors in the megaloblastic process?
A. Ordered arrangement of chromatin
B. Asynchrony
C. Eccentric nucleus
D. Pale cytoplasm
L.O. 6.2
2. What would be an appropriate M:E ratio in the case of megaloblastic anemia?
A. 1:3
B. 4:1
C. 5:1
D. 1:10
L.O. 6.1 & 6.4
3. Which of the following can distinguish treated versus untreated megaloblastic anemia?
A. Polychromasia
B. Hypochromia
C. Howell-Jolly bodies
D. Siderocytes
L.O. 6.9 & 6.10
4. Which of the following is a key substance required for the incorporation of vitamin B12 in the nuclear synthesis of red blood cells?
A. EPO
B. Transferrin
C. Intrinsic factor
D. Cytokines
L.O. 6.5
5. Evidence of ineffective erythropoiesis in the CBC of patients with megaloblastic anemia are:
A. Anemia, thrombocytopenia, leukopenia
B. Anemia, thrombocytosis, leukopenia
C. Anemia, thrombophilia, leukocytosis
D. Anemia, thrombocytosis, leukopenia
L.O. 6.4
6. All of the following are possible causes of low levels of intrinsic factor (IF) except which statement?
A. Partial gastrectomy may lead to the lack of IF.
B. Fifty-six percent of patients with pernicious anemia have antibodies to IF.
C. Atrophic gastritis may lead to the lack of IF.
D. Kidney failure may lead to lack of IF.
L.O. 6.8
7. Which MCV range is indicative of pernicious anemia?
A. 70 to 80 fL
B. 85 to 95 fL
C. 110 to 120 fL
D. 90 to 98 fL
L.O. 6.9
8. Which of the following red blood cell morphologies is classic in the megaloblastic anemias?
A. Polychromasia
B. Macroovalocytes
C. Basophilic stippling
D. Hypochromia
L.O. 6.3
9. A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:
A. Chemotherapy
B. Postsplenectomy
C. Hypoglycemic patients
D. Reticulocytosis
L.O. 6.11
10. Which of the following describes ineffective erythropoiesis?
A. An increase in the M:E ratio
B. A synthetic defect in hemoglobin
C. Premature destruction of red blood cell precursors
D. A DNA maturation defect
L.O. 6.4
11. Intrinsic factor is secreted by the:
A. Parietal cells of the stomach
B. Ileum
C. Thyroid
D. Bone marrow
L.O. 6.5
12. One of the most common pathophysiologies that contribute to folic acid deficiency is:
A. Tropical sprue
B. Intrinsic factor deficiency
C. IDA
D. Infection with Diphyllobothrium latum
L.O. 6.7
13. The Schilling test continues to be a historic reference method for the determination of:
A. IDA
B. Pernicious anemia
C. Folic acid deficiency
D. Hereditary hemochromatosis
L.O. 6.8
14. Macrocytic red blood cells are routinely seen in all the following except:
A. Pernicious anemia
B. Liver disease
C. Response to anemic stress
D. Thalassemia
L.O. 6.3 & 6.11
15. Which of the following is a clinical symptom specific to megaloblastic anemia?
A. Fever
B. Numbness and trouble with balance
C. Pallor
D. Splenomegaly
L.O. 6.6
NARRBEGIN:
NARREND
16. The cell pictured here may be seen in which of the following conditions?
A. Iron-deficiency anemia
B. Megaloblastic anemia
C. Thalassemia major
D. Hereditary hemochromatosis
NAR: Figure 6-4
L.O. 6.3
NARRBEGIN:
NARREND
17. The stage of development of the cell at the end of the pointer is a(n):
A. Polychromatophilic normoblast
B. Reticulocyte
C. Rubricyte
D. Orthochromatic normoblast
NAR: Figure 6-2
L.O. 6.2
True/False
18. A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.
L.O. 6.9
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Test Bank | Hematology in Practice 3e by Betty Ciesla
By Betty Ciesla