Verified Test Bank Epidemiology Of Alzheimer’S Disease Ch.48 - Test Bank | Epidemiology of Chronic Disease 2e by Harris by Randall E. Harris. DOCX document preview.

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Verified Test Bank Epidemiology Of Alzheimer’S Disease Ch.48

Chapter 48. Epidemiology of Alzheimer’s Disease

TEST BANK

True/False Questions

  1. Alzheimer’s disease causes more than 2 million deaths annually in the world population.
  2. The major factor responsible for the increasing incidence, prevalence, and mortality rates of Alzheimer’s disease is undoubtedly the increasing longevity in populations throughout the world.
  3. The incidence of Alzheimer’s disease doubles every 5 years after 65 years of age for men and women.
  4. All of the classical risk factors for ischemic heart disease and stroke have been found to increase the risk of Alzheimer’s disease.
  5. Studies funded by the tobacco industry suggest that smoking significantly increases the risk of developing Alzheimer’s disease.
  6. Obesity during midlife increases the risk of subsequently developing Alzheimer’s disease.
  7. Low blood level of homocysteine increases the risk of developing Alzheimer’s disease.
  8. Estrogen replacement therapy (ERT) has a positive risk benefit ratio.
  9. Familial Alzheimer’s disease accounts for 5-10% of cases.
  10. Vascular dementia accounts for about 30% of cases of dementia.
  11. Alzheimer’s disease, vascular dementia, and Lewy Body dementia, alone or in combination, account for about 95% of all cases of dementia.
  12. Lewy Body dementia exhibits many of the features of Parkinson’s disease.
  13. Clinical and neuropathologic features of dementia are nearly always concordant.
  14. Aggressive administration of currently available medications show significant clinical benefits in patients diagnosed with dementia.
  15. Treatment of cardiovascular risk factors in middle aged and older individuals may represent an important strategy for decreasing the incidence of dementia and for slowing the progression of cognitive decline.

Multiple Choice Questions

  1. Alzheimer’s disease accounts for about what percentage of all cases of dementia?
    1. 50%
    2. 60%
    3. 70%
    4. 80%
  2. Major risk factors for Alzheimer’s disease include all of the following except:
    1. obesity in midlife.
    2. hypertension.
    3. type 2 diabetes.
    4. low homocysteine.
  3. What is the approximate increase in the risk of developing Alzheimer’s disease after age 65 years?
    1. The risk increases by 50% every 5 years.
    2. The risk doubles every 5 years.
    3. The risk triples every 5 years.
    4. The risk remains unchanged with aging.
  4. Favorable prognostic indicators for survival in patients newly diagnosed with Alzheimer’s disease include all of the following except:
    1. mild disease.
    2. young age.
    3. being female.
    4. being male.
  5. Mutant forms of all of the following genes predispose to Alzheimer’s disease except:
    1. Presenilin 1 (PSEN-1).
    2. Presenilin 2 (PSEN-2).
    3. Sortilin-Related Receptor 1 (SORL1).
    4. Amyloid beta Precursor Protein (APP).
    5. HLA-B27.
  6. Which allele of the APOE locus increases the risk of Alzheimer’s disease?
    1. Apolipoprotein-E1 (APOEε1)
    2. Apolipoprotein-E2 (APOEε2)
    3. Apolipoprotein-E3 (APOEε3)
    4. Apolipoprotein-E4 (APOEε4)
  7. Lewy Body dementia is characterized by all of the following except:
    1. Parkinsonian symptoms.
    2. clumps of alpha-synuclein and ubiquitin protein in neurons.
    3. declining levels of the neurotransmitter acetylcholine.
    4. gradual progression.
  8. Approximately what percentage of dementia cases demonstrate mixed neuropathologic features?
    1. 5-10%
    2. 10-15%
    3. 15-20%
    4. 20-25%

Essay Questions

  1. Characterize the different forms of dementia.

  1. Characterize the global epidemiology of dementia.

  1. Discuss the pathogenesis of Alzheimer’s disease.

Amyloid plaques neurofibrillary tanglesmicroscopybeta-amyloidamyloid precursor proteinsenile plaques

  1. Discuss risk factors for Alzheimer’s disease.

  1. Describe the changing pattern of body mass that is characteristic of patients who develop Alzheimer’s disease.

  1. Discuss results of studies of estrogen replacement therapy and Alzheimer’s disease.

  1. Characterize genetic factors that predispose to Alzheimer’s disease.

PSEN2

  1. Discuss the etiology of vascular dementia.

  1. Describe Lewy Body dementia and its relationship with Parkinson’s disease.

  1. Discuss strategies for the prevention, control, and treatment of Alzheimer’s disease and other forms of dementia.

Document Information

Document Type:
DOCX
Chapter Number:
48
Created Date:
Aug 21, 2025
Chapter Name:
Chapter 48 Epidemiology Of Alzheimer’S Disease
Author:
Randall E. Harris

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