Test Bank Chapter 49 Epidemiology Of Parkinson’S Disease - Test Bank | Epidemiology of Chronic Disease 2e by Harris by Randall E. Harris. DOCX document preview.

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Test Bank Chapter 49 Epidemiology Of Parkinson’S Disease

Chapter 49. Epidemiology of Parkinson’s Disease

TEST BANK

True/False Questions

  1. Parkinson’s disease is characterized by death of neurons in the substantia nigra of the midbrain resulting in a deficit of the important neurotransmitter, dopamine.
  2. Misfolded forms of the protein, alpha-synuclein, accumulate in abnormal inclusions called Lewy Bodies that cause the death of neurons in Parkinson’s disease.
  3. Familial clustering of Parkinson’s disease is associated with heritable missense mutations in the gene encoding alpha-synuclein.
  4. In 2005, approximately 4.1 million people were suffering from Parkinson’s disease.
  5. In the US population, Parkinson’s disease is diagnosed in about 1% of adults over the age of 60 years and 4% over the age of 80 years.
  6. Parkinson’s disease is frequently diagnosed in adults under 50 years of age.
  7. The age-specific prevalence of Parkinson’s disease is higher in women than men.
  8. Smoking increases the risk of developing Parkinson’s disease.
  9. Autosomal dominant and autosomal recessive genes have been discovered that cause familial Parkinson’s disease.
  10. After crossing the blood brain barrier, MPTP is converted to a neurotoxic compound specific for neurons of the substantia nigra.
  11. MPTP has a chemical structure similar to many pesticides and herbicides.
  12. Excess exposure to certain pesticides and herbicides has not been proven to increase the risk of developing Parkinson’s disease.
  13. Excess exposure to manganese increases the risk of developing Parkinson’s disease.
  14. Regular use of NSAIDs has no influence on the risk of developing Parkinson’s disease.
  15. Dementia is an uncommon development in patients with Parkinson’s disease.

Multiple Choice Questions

  1. Approximately what percentage of cases of Parkinson’s disease are diagnosed in adults 50 years or older?
    1. 50%
    2. 75%
    3. 90%
    4. 99%
  2. Risk factors for Parkinson’s disease include all of the following except:
    1. excess exposure to pesticides and/or herbicides.
    2. excess exposure to manganese.
    3. genetic predisposition.
    4. chronic tobacco smoking.
  3. What is the approximate cumulative risk of developing Parkinson’s disease during one’s lifetime?
    1. 0-1%
    2. 2-3%
    3. 4-5%
    4. 6-7%
  4. Favorable prognostic indicators for survival in patients newly diagnosed with Alzheimer’s disease include all of the following except:
    1. mild disease.
    2. young age.
    3. being female.
    4. being male.
  5. Mutant forms of all of the following genes predispose to Parkinson’s disease except:
    1. BRCA-1,2.
    2. Parkin.
    3. Leucine Rich Repeat Protein Kinase (LRRK2).
    4. alpha-synuclein (SNCA).
    5. PTEN-induced kinase (PINK-1).
  6. All of the following have been found to protect against the development of Parkinson’s disease except:
    1. coffee consumption.
    2. cigarette smoking.
    3. regular intake of NSAIDs.
    4. repeated head trauma.
  7. Lewy Body dementia is characterized by:
    1. Parkinsonian symptoms.
    2. clumps of alpha-synuclein and ubiquitin protein in neurons.
    3. declining levels of the neurotransmitter, acetylcholine.
    4. gradual progression.
  8. Indicators of a poor prognosis for patients diagnosed with Parkinson’s disease include all of the following except:
    1. APOE ε4 genotype.
    2. avoidance of caffeine.
    3. continuation of cigarette smoking.
    4. smoking cessation.

Essay Questions

  1. Characterize the pathologic features of Parkinson’s disease.

LatinneuromelanindopaminergicneuronsParkinson's diseasepars compacta

  1. Discuss the molecular biology of Parkinson’s disease.

  1. Discuss the global distribution of Parkinson’s disease.

  1. Discuss risk factors for Parkinson’s disease.

  1. Discuss results of studies of cigarette smoking and Parkinson’s disease.

  1. Describe rare genetic syndromes that predispose to the development of familial Parkinson’s disease.

  1. What are the effects of MPTP exposure on the neurons of the substantia nigra?

dopamine-producingneuronssubstantia nigraelectron transport chain

  1. Discuss results of studies of Parkinson’s disease and exposure to herbicides/pesticides.

  1. Discuss manganese exposure and Parkinson’s disease.

  1. Discuss strategies for the prevention, control, and treatment of Parkinson’s disease and other forms of dementia.

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Document Information

Document Type:
DOCX
Chapter Number:
49
Created Date:
Aug 21, 2025
Chapter Name:
Chapter 49 Epidemiology Of Parkinson’S Disease
Author:
Randall E. Harris

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