Fibrinogen, Thrombin, and the | Verified Test Bank Ch.18

Chapter 18. Fibrinogen, Thrombin, and the Fibrinolytic System

Multiple Choice

1. The process of fibrin degradation is called __________ and is controlled by the enzyme _________.

A. fibrination; plasmin

B. fibrinolysis; plasmin

C. fibrination; protease

D. fibrinolysis; protease

L.O. 18.1

2. All of the following are functions of thrombin except:

A. Initiating the platelet release reaction

B. Simulating platelets to product PGI₂

C. Activating factors V and VIII

D. Activating thromboplastin

L.O. 18.3

3. A primary inhibitor of the fibrinolytic system is:

A. Alpha 2 antiplasmin

B. Alpha 2 macroglobulin

C. Antithrombin

D. Protein C

L.O. 18.1

4. D-dimer analysis may have what kind of result in DIC?

A. Normal

B. Low

C. Elevated

D. D-dimer is not an appropriate test for DIC.

L.O. 18.6

5. Which of these are byproducts of fibrinolysis?

A. Fibrin degradation products and D-dimers

B. Fibrinopeptides A and B

C. Streptokinase and urokinase

D. Alpha 2 antiplasmins

L.O. 18.6 & 18.7

6. The reference range for fibrinogen is:

A. 20 to 40 mg/dL

B. 100 to 120 mg/dL

C. 150 to 450 mg/dL

D. 200 to 400 mg/dL

L.O. 18.6

7. Which of the following hematology disorders will likely trigger an episode of DIC?

A. Sickle cell disease

B. Iron-deficiency anemia

C. Idiopathic thrombocythemia

D. Acute promyelocytic leukemia

L.O. 18.5

8. The lowest levels of fibrinogen are seen in which inherited disorder of fibrinogen?

A. Hyperfibrinogenemia

B. Hypofibrinogenemia

C. Dysfibrinogenemia

D. Afibrinogenemia

L.O. 18.4

9. The D-dimer test measures:

A. Fibrinogen deposition

B. Fibrinogen degradation

C. Fibrin degradation

D. Fibrin deposition

L.O. 18.6 & 18.7

10. Obstetrical complications such as retained placenta or abruptio placenta are leading causes of:

A. Thrombosis

B. DIC

C. ITP

D. TTP

L.O. 18.5

11. The substrate upon which the coagulation cascade is centered is:

A. Thrombin

B. Vitamin K

C. Fibrinogen

D. Fibrin

L.O. 18.1

12. The key component to clot dissolution is:

A. Plasminogen

B. Plasmin

C. Thrombin

D. Fibrin

L.O. 18.2

13. Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

A. 0 to 20 mg/dL

B. 20 to 100 mg/dL

C. 50 to 150 mg/dL

D. 100 to 200 mg/dL

L.O. 18.4

14. The best component to use for patients with afibrinogenemia is:

A. Whole blood

B. Fresh frozen plasma

C. Tissue plasminogen activator

D. Factor XIII

L.O. 18.4

15. A patient with DIC will have all the following coagulation test results except:

A. An increased PT/INR

B. An increased aPTT

C. An increased fibrinogen

D. An increased D-dimer

L.O. 18.6

16. An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

A. D-dimers

B. Alpha-2-antiplasmin

C. Protein C

D. Plasmin

L.O. 18.6 & 18.7

17. A patient with DIC will have the all following coagulation test results except:

A. An increased PT/INR

B. An increased aPTT

C. An increased fibrinogen

D. An increased D-dimer

L.O. 18.6

18. Plasmin causes the inactivation of factors:

A. V, VII, X, XI

B. V, VIII, XI, XII

C. VII, VIII, XI, XII
D. X, XI, XII, XIII

L.O. 18.2

19. Primary fibrinolysis is a disorder closely related to DIC. All of the coagulation profile assays are the same as that for DIC with the exception of the:

A. D-dimer level, which is increased

B. Fibrinogen level, which is decreased

C. Platelet count, which is normal

D. PT/INR, which is increased

L.O. 18.1 & 18.6

20. Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

A. Less than 20 µg/mL

B. Less than 40 µg/mL

C. Less than 75 µg/mL

D. Less than 100 µg/mL

L.O. 18.6 & 18.7