Test Questions & Answers Ch19 Introduction to Thrombosis and

Chapter 19. Introduction to Thrombosis and Anticoagulant Therapy

Multiple Choice

1. All of the following statements describe factor V Leiden except:

A. It is a cause of activated protein C resistance.

B. It is associated with thrombocytopenia.

C. It is associated with increased risk of thrombosis.

D. Is an inherited disorder.

L.O. 19.4 & 19.6

2. The international normalized ratio (INR) is useful in:

A. The detection of coagulation factor deficiencies

B. Monitoring heparin therapy

C. The detection of inhibitors

D. Monitoring Coumadin therapy

L.O. 19.11

3. Heparin:

A. Inhibits PF3

B. Inhibits thrombin

C. Degrades antithrombin

D. Forms a complex with protein C

L.O. 19.9

4. All of the following statements are true regarding Coumadin except:

A. It is a vitamin K antagonist.

B. It needs antithrombin as a cofactor.

C. PT is used to monitor its dosage.

D. It is not recommended for pregnant and lactating women.

L.O. 19.10

5. Which of the following PT results would most likely be seen in a patient who is on Coumadin and is stable?

A. Approximately 26 seconds

B. Approximately 13 seconds

C. Approximately 40 seconds

D. Approximately 60 seconds

L.O. 19.11

6. The lupus anticoagulant is directed against:

A. Factor VIII

B. Factor X

C. Factor IX

D. Phospholipids

L.O. 19.5

7. Coumadin acts in such a way that it:

A. Alters the synthesis of vitamin K−dependent factors

B. Reduces the circulating level of factors III and V

C. Reduces the circulating level of factor I

D. Cleaves carboxyreductase to generate glutamic acid

L.O. 19.9 & 19.10

8. Heparin-induced thrombocytopenia (HIT) usually:

A. Occurs as a result of protein C deficiency

B. Will show an increase in platelets

C. Occurs 5 to 14 days after heparin therapy

D. Occurs only in males

L.O. 19.7

9. Factor Xa inhibitors are monitored using which assay?

A. APTT

B. PT

C. anti-factor Xa assay

D. platelet count

L.O. 19.12

10. What is the term for the condition that predisposes patients to thrombosis?

A. Thrombopenia

B. Thrombophilia

C. Thrombocytosis

D. Anemia

L.O. 19.1

11. All of the following can cause thrombosis except:

A. Low platelet count

B. Activation of coagulation systems

C. Vascular injury

D. Deficiencies of coagulation inhibitors

L.O. 19.2

12. Arterial thrombosis is associated with:

A. Antithrombin deficiency

B. Protein S deficiency

C. Protein C deficiency

D. Both protein S and C deficiencies

L.O. 19.3

13. Which test should be ordered as a baseline before started heparin therapy on a patient?

A. PT

B. Platelet count

C. APTT

D. Fibrinogen

L.O. 19.8

14. All of the following are naturally occurring thrombin inhibitors except:

A. AT

B. Prothrombin cofactor II

C. Protein C

D. Plasmin

L.O. 19.3

15. Protein C is activated by which of the following?

A. Heparin cofactor II

B. Factor VIIIa

C. Antithrombin

D. Protein S

L.O. 19.3

16. The most common tests used to detect lupus anticoagulants include all of the following except:

A. aPTT

B. Kaolin clotting time

C. PT/INR

D. Dilute Russell viper venom test

L.O. 19.5

17. Drug alternatives for patients with heparin-induced thrombocytopenia include:

A. Danaparoid

B. Warfarin

C. Streptokinase

D. Aspirin

L.O. 19.13

18. Heparin therapy is monitored best by performing routine:

A. PT/INRs

B. Anti-factor Xa

C. Fibrinogen levels

D. Bleeding time tests

L.O. 19.10

19. The target therapeutic range for an INR in patients with thromboembolic disease is:

A. 1 to 2

B. 1.5 to 2.5

C. 2 to 3

D. 2 to 2.5

L.O. 19.11

20. Antithrombin inhibits all of the following factors except:

A. IIa

B. VIIa

C. IXa

D. XIa

L.O. 19.3