Epidemiology Of Sarcoma Ch35 Exam Prep - Test Bank | Epidemiology of Chronic Disease 2e by Harris by Randall E. Harris. DOCX document preview.

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Epidemiology Of Sarcoma Ch35 Exam Prep

Chapter 35. Epidemiology of Sarcoma

TEST BANK

True/False Questions

  1. Sarcomas are rare tumors of connective tissue, primarily arising in soft tissue or bone.
  2. About 30% of bone sarcomas are diagnosed prior to age 20, after which the incidence steadily declines with age.
  3. The death curve for bone sarcomas shows an early peak during adolescence and a late peak at 75-85 years of age.
  4. The incidence of soft tissue sarcomas is relatively constant over the life span.
  5. The death curve for soft tissue sarcoma increases gradually over the life span and shows a single peak late in life.
  6. Reciprocal chromosomal translocations constitute the majority of specific genetic alterations associated with pediatric sarcomas.
  7. It is likely that the chimeric fusion proteins resulting from reciprocal translocations act as transcription activators that deregulate key genes associated with pediatric sarcoma development.
  8. Chimeric fusion proteins resulting from reciprocal translocations provide potential targets for the therapy of pediatric sarcomas with monoclonal antibodies.
  9. Adult sarcomas are often characterized by reciprocal translocations and chimeric fusion proteins.
  10. Lipomas are benign tumors that develop from adipose tissue.
  11. Uterine fibroids are benign tumors that develop from endometrial tissue.
  12. Lipomas and uterine fibroids often undergo malignant transformation.
  13. Nearly all Gastrointestinal Stromal Tumors (GIST) have been found to carry mutant forms of an important tyrosine kinase receptor gene called c-KIT.
  14. There is consistent evidence that radiation exposure increases the risk of developing both bone and soft tissue sarcomas.
  15. The primary cause of Kaposi’s sarcoma is HIV infection.

Multiple Choice Questions

  1. Kaposi’s sarcoma arises from:
    1. soft connective tissue.
    2. macrophages.
    3. endothelial cells of blood vessels.
    4. pigmented nevi.
  2. The most common malignancy in sub-Saharan Africa is:
    1. Burkitt’s lymphoma.
    2. leukemia.
    3. Kaposi’s sarcoma.
    4. lung cancer.
  3. The defining genetic abnormality of gastrointestinal stromal tumors (GIST) is the presence of a mutant form of which of the following genes?
    1. PAX
    2. c-KIT
    3. SYT
    4. EWSR-1
  4. What is the approximate annual incidence rate of sarcoma in individuals under the age of 20 years in the US population?
    1. 1 per million
    2. 10 per million
    3. 50 per million
    4. 10 per 100,000
  5. Sarcomas account for about what percentage of malignant neoplasms in children and adolescents?
    1. 1%
    2. 13%
    3. 25%
    4. 50%
  6. Sarcomas account for about what percentage of malignant neoplasms in adults?
    1. 0-1%
    2. 1-5%
    3. 6-10%
    4. >10%
  7. The signature reciprocal chromosomal translocation responsible for synovial sarcoma involves which genes?
    1. SYT on chromosome 18 and SSX on the X chromosome
    2. FKHR on chromosome 13 and PAX on chromosomes 1 and 2
    3. ETV6 on chromosome 12 and NTRK3 on chromosome 13
    4. EWSR-1 on chromosome 22 and FLI-1 on chromosome 11
  8. The virus that causes Kaposi’s sarcoma is:
    1. HIV-1.
    2. HIV-2.
    3. HHV-2.
    4. HHV-8.
  9. How do reciprocal chromosomal translocations cause the development of many forms of pediatric sarcoma?
    1. They create new genes that code chimeric fusion proteins with oncogenic potential.
    2. They increase the formation of reactive oxygen species.
    3. They create new tumor suppressor genes.
    4. They increase epigenetic effects.
  10. Chronic exposure to polyvinyl chloride increases the risk of developing which of the following types of sarcoma?
    1. Fibrosarcoma
    2. Liposarcoma
    3. Leiomyosarcoma
    4. Angiosarcoma

Essay Questions

  1. Define the various subtypes of sarcoma.

  1. Characterize the epidemiology of pediatric sarcoma in the USA.

  1. Briefly characterize the epidemiology of adult sarcoma in the USA.

  1. Discuss the major exogenous risk factors for sarcoma.

  1. Discuss the pathogenesis of pediatric sarcoma.

  1. Describe the signature reciprocal chromosomal translocation that causes synovial sarcoma.

  1. Describe reciprocal chromosomal translocations that cause Ewing’s sarcoma.

  1. Discuss the genetic mutation that is responsible for GIST.

  1. Describe key findings of epidemiologic studies of PVC exposure and angiosarcoma.

  1. Discuss the global epidemiology of Kaposi’s sarcoma.

Document Information

Document Type:
DOCX
Chapter Number:
35
Created Date:
Aug 21, 2025
Chapter Name:
Chapter 35 Epidemiology Of Sarcoma
Author:
Randall E. Harris

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