Complete Test Bank Ch4 Hemoglobin Function and Principles of

Chapter 4. Hemoglobin Function and Principles of Hemolysis

Multiple Choice

1. What percentage of hemoglobin is synthesized in the reticulocyte stage?

A. 65%

B. 95%

C. 35%

D. 45%

L.O. 4.4

2. Epsilon and zeta chains are part of which of the following hemoglobins?

A. Hemoglobin Portland

B. Hemoglobin F

C. Hemoglobin A

D. Hemoglobin A₂

L.O. 4.6

3. Fetal hemoglobin consists of which of the following chains?

A. α₂β₂

B. α₂γ₂

C. α₂δ₂

D. α₂ε₂

L.O.4.6

4. Which of the following variables affect how the hemoglobin molecule either holds on to or releases oxygen?

A. Amount of alpha or beta chains

B. Relationship between the pulmonary and venous circulations

C. Viscosity of the blood

D. Ferritin levels

L.O. 4.8

5. Which of the following abnormal hemoglobins will result in a cyanotic condition?

A. Sulfhemoglobin

B. Cyanmethemoglobin

C. Hemoglobin F

D. Hemoglobin M

L.O. 4.10

6. Each hemoglobin molecule consists of four ____ .

A. alpha chain molecules

B. beta chain molecules

C. heme molecules with with Fe²⁺

D. heme molecules with Fe³⁺

L.O. 4.1

7. Which of the following factors will result in an immediate increase in oxygen delivery to the tissues?

A. Increased pH

B. Increased altitude

C. Increased 2,3-DPG

D. Increased carboxyhemoglobin

L.O. 4.9

8. How many genes are responsible for the productions of alpha chains?

A. Two

B. One

C. Three

D. Four

L.O. 4.7

9. Which of the following clinical conditions is a definitive sign of intravascular lysis?

A. Bilirubinemia

B. Decreased RBC count

C. Hemoglobinuria

D. Elevated LDH

L.O. 4.11

10. Which organ(s) is(are) the most affected during extravascular lysis?

A. Liver and spleen

B. Kidneys

C. Pancreas

D. Heart

L.O. 4.12

11. Each hemoglobin molecule consists of ____ globin structures.

A. two

B. four

C. six

D. eight

L.O. 4.1 & 4.2

12. Physiological conditions in the body that can decrease hemoglobin’s oxygen affinity include:

A. Increased pH

B. Decreased 2,3-DPG

C. Increased body temperature

D. The presence of abnormal hemoglobins

L.O. 4.9

13. When iron is present in an oxidized state as Fe⁺³ or ferric iron, the resulting hemoglobin is known as:

A. Methemoglobin

B. Carboxyhemoglobin

C. Sulfhemoglobin

D. Deoxyhemoglobin

L.O. 4.10

14. ________ may be seen in intravascular hemolysis but not in extravascular hemolysis.

A. Hemoglobinuria

B. Splenomegaly

C. Increased LDH

D. Elevated serum bilirubin

L.O. 4.13

15. Intrinsic red cell defects that can lead to hemolysis include:

A. Environmental effects

B. Inherited deficiencies

C. A shift in pH

D. A decrease in G6PD

L.O. 4.14

16. Which of the following is not a normal adult hemoglobin?

A. Hgb A

B. Hgb Portland

C. Hgb F

D. Hgb A₂

L.O. 4.5

True/False

17. Hemoglobin begins to be synthesized at the polychromatophilic stage of red blood cell development.

L.O. 4.4

18. Abnormal hemoglobins have a lower affinity for oxygen.

L.O. 4.10

19. Ninety percent of in vivo hemolysis is intravascular.

L.O. 4.11

20. Oxygen delivery is the primary purpose of hemoglobin.

L.O. 4.3