Acute Leukemias Chapter.11 Exam Questions

Chapter 11. Acute Leukemias

Multiple Choice

1. The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

A. Replacement of normal marrow precursors by leukemic cells

B. Decrease in functional leukocytes causing infection

C. Hemorrhage secondary to thrombocytopenia

D. Decreased erythropoietin production

L.O. 11.1

2. Migration to extramedullary sites is a feature of which of the following leukemias?

A. Acute progranulocytic leukemia

B. Acute myelocytic leukemia

C. Acute monocytic leukemia

D. Acute lymphocytic leukemia

L.O. 11.2 & 11.3

3. A patient presents with generalized lymphadenopathy and a WBC of 100 × 10⁹/L. This hematologic picture would most likely be seen in:

A. Chronic lymphocytic leukemia

B. Acute lymphocytic leukemia

C. Burkitt’s lymphoma

D. Hairy cell leukemia

L.O. 11.1

4. A patient with AML is likely to have a cytochemical stain panel that is positive for:

A. Sodium fluoride with tartrate resistance

B. MPO, SBB, specific esterase

C. MP0, SBB, nonspecific esterase

D. SBB and TdT

L.O. 11.4

5. The monoclonal marker that is often positive in T-ALL is:

A. CD1

B. CD7

C. CD10

D. CD41

L.O. 11.6

6. The translocation t(15:17)(q22;q12) is associated with which of the following leukemias?

A. Acute promyelocytic leukemia

B. Acute myelomonocytic leukemia

C. Acute lymphocytic leukemia

D. Acute myelocytic leukemia

L.O. 11.5

7. Acute leukemic processes are marked by:

A. Slow onset, slow progression, anemia

B. Rapid onset anemia, thrombocytopenia

C. Splenomegaly

D. Less than 30% in the BM

L.O. 11.1

8. Which of the following is characteristic of Auer rods?

A. Composed of fused primary granules

B. Predominantly seen in ALL

C. Predominantly seen in HCL

D. Composed of specific granules

L.O. 11.2

9. When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells. The peripheral smear showed large multilobulated blast cells. This pattern is most representative of:

A. ALL

B. AMonoL

C. AMML

D. AML

L.O. 11.6

10. Which CD marker best represents the earliest progenitor cells?

A. CD11

B. CD19

C. CD34

D. CD57

L.O. 11.6

11. According to current WHO classification criteria, acute leukemia is characterized by which of the following?

A. Hypercellular bone marrow with greater than 20% blasts

B. Hypercellular bone marrow with less than 20% blasts

C. Hypocellular bone marrow with greater than 20% blasts

D. Hypocellular bone marrow with less than 20% blasts

L.O. 11.7

12. Pure erythroid leukemia is defined as:

A. Erythroid precursors greater than 30%, myeloblasts less than 20%

B. Erythroid precursors greater than 50%, myeloblasts less than 40%

C. Erythroid precursors less than 50%

D. Erythroid precursors greater than 80%

L.O. 11.2

13. The leukemia with a predominance of WBC cells positive for CD41 is:

A. AMML

B. AML

C. AMonoL

D. AMegL

L.O. 11.6

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NARREND

14. The cells pictured here are most consistent for:

A. Acute myeloid leukemia

B. Acute myelomonocytic leukemia

C. Acute lymphoblastic leukemia

D. Acute erythroid leukemia

NAR: Figure 11-2

L.O. 11.2

NARRBEGIN:

NARREND

15. The cells pictured here are most consistent with:

A. Acute myeloid leukemia

B. Acute myelomonocytic leukemia

C. Acute lymphoblastic leukemia

D. Acute erythroid leukemia

NAR: Figure 11-11A

L.O. 11.2

16. The presence of CD2, CD5, and CD7 and the absence of CD10 is seen in:

A. B lymphocytes

B. T lymphocytes

C. Myeloblasts

D. Monoblasts

L.O. 11.6

NARRBEGIN:

NARREND

17. The structure at the end of the pointer is a(n):

A. Auer rod

B. Döhle body

C. Engulfed bacteria

D. None of the above

NAR: Figure 11-11C

L.O. 11.2

18. _____ is predominantly a disease of children.

A. AML

B. CML

C. ALL

D. CLL

L.O. 11.7

19. Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

A. 10%

B. 20%

C. 25%

D. 30%

L.O. 11.7

20. Pediatric patients with ALL have an overall complete remission rate of:

A. 50%

B. 65%

C. 75%

D. 85%

L.O. 11.8