Chapter.12 Test Bank Docx Myeloproliferative Neoplasms - Test Bank | Hematology in Practice 3e by Betty Ciesla by Betty Ciesla. DOCX document preview.
Chapter 12. Myeloproliferative Neoplasms
Multiple Choice
1. A term describing a peripheral blood finding of leukocytosis with a shift to the left accompanied by occasional nucleated red cells and platelet abnormalities is:
A. Dysplasia
B. Leukoerythroblastic
C. Megaloblastoid
D. Leukemoid
L.O. 12.6
2. The accelerated phase of chronic myeloid leukemia is marked by:
A. Increased basophils
B. Thrombocytopenia
C. Increase in blasts
D. Increased fibrosis
L.O. 12.6 & 12.7
3. Pancytosis is a prominent feature of which of the following disorders?
A. Chronic myelocytic leukemia
B. Idiopathic myelofibrosis
C. Polycythemia vera
D. Essential thrombocythemia
L.O. 12.2 & 12.3 & 12.6 & 12.7
4. A patient has the following CBC results:
WBC count: 35 × 109/L
Differential: 60 segmented neutrophils
12 lymphocytes
8 metamyelocytes
10 band neutrophils
7 monocytes
3 eosinophils
Platelets: Normal
RBC morphology: Normocytic, normochromic
LAP score: 5
These results are consistent with:
A. Chronic myelocytic leukemia
B. Reaction to severe infection
C. Acute leukemia
D. Polycythemia vera
L.O. 12.3 & 12.6 & 12.7
5. What is the pathophysiology of the myeloproliferative disorders?
A. Fibroid infiltration of major organs
B. Neoplastic transformation of multipotential stem cells
C. Widespread deterioration of cellular function
D. Splenic sequestration of normal blood cells
L.O. 12.1 & 12.4
6. Myocardial infarctions, transient ischemic attacks, and deep vein thrombosis are likely to be complications of:
A. Chronic myelocytic leukemia
B. Acute myelocytic leukemia
C. Polycythemia vera
D. Myelofibrosis with myeloid metaplasia
L.O. 12.2 & 12.5
7. A “dry tap” is a characteristic of myeloid fibrosis with myeloid metaplasia due to increased infiltration of:
A. Blast cells
B. Abnormal platelets
C. Abnormal red cells
D. Fibrotic elements
L.O. 12.5
8. What effect does the Ph chromosome have on the prognosis of patients with chronic myelocytic leukemia?
A. It is not predictive.
B. The prognosis is better if the Ph chromosome is present.
C. The prognosis is worse if the Ph chromosome is present.
D. The disease usually transforms into AML when the Ph chromosome is present.
L.O. 12.10
9. The red cell morphology associated with PMF is:
A. Burr cells
B. Acanthocytes
C. Teardrop cells
D. Target cells
L.O. 12.6
10. A high-risk factor for the diagnosis of essential thrombocythemia is:
A. A platelet count greater than 600,000
B. Extramedullary hematopoiesis
C. The presence of BCR/ABL
D. Fibrotic bone marrow
L.O. 12.2 & 12.3 & 12.6
11. The translocation of genetic material t9:22 is associated with:
A. The Philadelphia chromosome
B. ALL
C. A leukemoid reaction
D. Polycythemia vera
L.O. 12.10
12. _______ indicates the transformation of a chronic process to an acute process.
A. An increased WBC count
B. Bone marrow fibrosis
C. The presence of the Philadelphia chromosome
D. An increase in the percentage of blasts in the peripheral blood or bone marrow
L.O. 12.9
13. Plethora is a condition associated with:
A. Polycythemia vera
B. CML
C. Leukemoid reaction
D. Myelofibrosis
L.O. 12.2 & 12.5 & 12.8
14. The JAK2 chromosomal mutation is associated with:
A. Polycythemia vera
B. CML
C. Leukemoid reaction
D. Myelofibrosis
L.O. 12.2 & 12.10
15. ________ has the worst prognosis of all the myeloproliferative disorders.
A. Polycythemic vera
B. Essential thrombocythemia
C. Primary myelofibrosis
D. Chronic myelogenous leukemia
L.O. 12.2 & 12.9
16. Essential thrombocytosis can affect all three cell lines, but the main cell line affected is the:
A. Megakaryocytes
B. Erythrocytes
C. Granulocytes
D. Lymphocytes
L.O. 12.3
17. Chronic myelogenous leukemia will present with less than _____ blasts in the peripheral blood.
A. 5%
B. 10%
C. 20%
D. 30%
L.O. 12.6
18. The highest concentration of eosinophils seen in peripheral smear is seen in which of the following?
A. CML
B. CEL
C. PV
D. ET
L.O. 12.6
True/False
19. Myeloproliferative neoplasms are disorders of the young.
L.O. 12.1
20. Patients with essential thrombocytosis do not experience fibrosis of their bone marrow.
ANS. True
L.O. 12.6
Document Information
Connected Book
Test Bank | Hematology in Practice 3e by Betty Ciesla
By Betty Ciesla