Test Bank Answers Pathogenesis Of Cancer Chapter 11 - Test Bank | Epidemiology of Chronic Disease 2e by Harris by Randall E. Harris. DOCX document preview.

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Test Bank Answers Pathogenesis Of Cancer Chapter 11

Chapter 11. Pathogenesis of Cancer

TEST BANK

True/False Questions

  1. Cancer is more likely to develop in those cell populations with higher rates of cell division.
  2. Cancer can be succinctly defined as “deranged cell division.”
  3. Progression through the cell cycle is tightly regulated by a family of genes called “cyclins” and the proteins they encode.
  4. Because of its important role in eliminating mutant cells and conserving genomic stability, the p53 gene has been deemed the “guardian of the human genome.”
  5. Approximately 90% of human cancer evolves from epithelial cell populations.
  6. Dysplasia is an intermediate step in the evolution of cancer.
  7. Carcinoma in situ has a poor prognosis.
  8. Invasive cancer implies a breach in the basement membrane.
  9. Alfred Knudsen proposed the “two-hit” model of carcinogenesis.
  10. The epigenetic theory of cancer involves base pair changes of DNA.

Multiple Choice Questions

  1. What percent of human cancers are carcinomas derived from proliferating epithelial cell populations?
    1. 25%
    2. 50%
    3. 75%
    4. 90%
  2. What biological process stimulates formation of new blood vessels?
    1. Apoptosis
    2. Angiogenesis
    3. Mitosis
    4. Immunosuppression
  3. What biological process regulates cell senescence?
  4. Apoptosis
  5. Angiogenesis
  6. Mitosis
  7. Immunosuppression
  8. What phenomenon of cancer causes death?
    1. Apoptosis
    2. Angiogenesis
    3. Metastasis
    4. Immunosuppression
  9. The epigenetic theory of cancer involves all of the following except:
    1. changes in gene expression.
    2. enhanced transcription of Proto-oncogenes.
    3. reduced expression of tumor suppressor genes.
    4. base pair changes in DNA.
  10. Mutations that are passed from parent to offspring are called:
    1. somatic mutations.
    2. germline mutations.
  11. Mutations that are derived from individual cells during the lifespan are called:
    1. somatic mutations.
    2. germline mutations.
  12. What are chief enzymes of the inflammatory cascades?
    1. Cylooxygenase-1
    2. Cylooxygenase-2
    3. ALOX5
    4. Telomerase
    5. All of the above are correct.
    6. Only a, b, c are correct.
  13. What family of enzymes are associated with invasive cancer?
    1. MMP
    2. Telomerase
    3. MAPK
    4. CHEK
  14. What enzyme prolongs cellular life by sustaining telomere integrity?
    1. MMP
    2. Telomerase
    3. MAPK
    4. CHEK

Essay Questions

  1. Discuss mechanisms of carcinogenesis.

  1. Discuss somatic mutations and carcinogenesis.

  1. Discuss angiogenesis and carcinogenesis.

  1. Discuss apoptosis and carcinogenesis.

  1. Discuss metastasis of cancer cells.

  1. Discuss immunosuppression and carcinogenesis.

  1. Discuss chronic inflammation and carcinogenesis.

Document Information

Document Type:
DOCX
Chapter Number:
11
Created Date:
Aug 21, 2025
Chapter Name:
Chapter 11 Pathogenesis Of Cancer
Author:
Randall E. Harris

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