Epidemiology Of Breast Cancer Chapter 21 Verified Test Bank - Test Bank | Epidemiology of Chronic Disease 2e by Harris by Randall E. Harris. DOCX document preview.

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Epidemiology Of Breast Cancer Chapter 21 Verified Test Bank

Chapter 21. Epidemiology of Breast Cancer

TEST BANK

True/False Questions

  1. Breast cancer was diagnosed in 2,088,849 women in 2018 and caused 626,679 deaths.
  2. Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women (only lung cancer causes more deaths).
  3. Survival of Stage I breast cancer (carcinoma in situ) approaches 100% in the US population.
  4. The classical risk factors for breast cancer include familial and genetic predisposition, early menses, delayed reproductive history, nulliparity, absence of lactation, late menopause, and the natural process of aging.
  5. Mammography has had little impact on breast cancer survival among cases diagnosed prior to menopause.
  6. Mammography has had little impact on breast cancer survival among cases diagnosed after menopause.
  7. Nearly 75% of breast cancers are detected in postmenopausal women.
  8. Hallmarks of familial breast cancer include early onset, bilateral disease, and clustering of other forms of cancer among female relatives.
  9. Estrogen replacement therapy increases the risk of breast cancer, endometrial cancer, and ovarian cancer.
  10. Genetic factors are responsible for the majority of breast cancer cases.

Multiple Choice Questions

  1. Breast cancer mortality has increased significantly during the past 50 years in all of the following countries except:
    1. Japan.
    2. India.
    3. China.
    4. France.
  2. Tumor suppressor genes linked to breast cancer pathogenesis include all of the following except:
    1. BRCA-1.
    2. BRCA-2.
    3. PTEN.
    4. RET.
  3. What is the karyotype of males with Klinefelter’s syndrome who occasionally develop breast cancer?
    1. XXY
    2. XXX
    3. XY
    4. XX
  4. Breast cancer occasionally occurs in men treated for metastatic prostate cancer with:
    1. diethylstilbestrol.
    2. Cytoxan.
    3. Methotrexate.
    4. Avastin.
  5. After menopause, the primary source of circulating estrogens is:
    1. ovarian biosynthesis.
    2. biosynthesis in the adrenal glands.
    3. aromatase-catalyzed biosynthesis in fat and muscle.
    4. biosynthesis in the endometrial glands.
  6. Animal studies and some human studies suggest that breast cancer risk is decreased by high intake of:
    1. n-6 fatty acids such as linoleic acid.
    2. n-3 fatty acids such as linolenic acid.
    3. saturated fat.
    4. fish oil.
    5. a and c are correct.
    6. b and d are correct.
  7. Arguments against the use of selective estrogen receptor modulators such as Tamoxifen for the chemoprevention of breast cancer include:
    1. the absence of statistically significant reductions in the incidence of breast cancer among women receiving the drug in some randomized clinical trials.
    2. lack of compliance in the trials.
    3. a significant increase in the death rate among women receiving the drug in one trial.
    4. heterogeneity of study design in all trials.
    5. Only a and c are correct.
    6. All answers are correct.
  8. Mammography has been shown to decrease breast cancer mortality in women over the age of 50 years by about:
    1. 20%.
    2. 30%.
    3. 40%.
    4. 50%.

Essay Questions

  1. Describe the global burden of breast cancer.

  1. Discuss the classical risk factors of breast cancer initially identified by Janet Lane-Claypon.

  1. Discuss the hallmarks of familial breast cancer and the effects of mutant forms of BRCA-1 and BRCA-2.

  1. Discuss estrogen replacement therapy and the risk of breast cancer in women with differing body mass.

  1. Discuss time trends in breast cancer mortality in Japan versus the United States and potential reasons for trend differences.

  1. Discuss the value of mammography in the early detection of breast cancer.

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Document Information

Document Type:
DOCX
Chapter Number:
21
Created Date:
Aug 21, 2025
Chapter Name:
Chapter 21 Epidemiology Of Breast Cancer
Author:
Randall E. Harris

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