Verified Test Bank Chapter 30 Epidemiology Of Kidney Cancer - Test Bank | Epidemiology of Chronic Disease 2e by Harris by Randall E. Harris. DOCX document preview.
Chapter 30. Epidemiology of Kidney Cancer
TEST BANK
True/False Questions
- In 2018, 403,262 new cases were diagnosed (254,507 in men and 148,755 in women), and 175,098 individuals died from kidney cancer (113,822 men and 61,276 women).
- Both the incidence and mortality of kidney cancer have steadily decreased in the past two decades.
- While the rising incidence rates of kidney cancer may be partially attributable to improvements in imaging techniques, better detection does not fully explain the worldwide increase in mortality.
- Renal cell carcinoma, arising from epithelial cells that line the renal tubules, is the most common type of kidney cancer, accounting for approximately 85-90% of all malignant kidney tumors.
- Transitional cell carcinomas, arising from epithelial cells at the junction of the renal pelvis and the ureter, constitute 5-10% of malignant kidney tumors.
- The risk factors for transitional cell carcinomas of the renal pelvis are synonymous with those for transitional cell carcinomas of the urinary bladder.
- The three major risk factors for renal cell carcinoma are tobacco smoking, hypertension, and obesity.
- Studies of clear cell renal cell carcinoma have found mutations in the von Hippel Lindau gene in approximately 90% of cases.
- The analgesic phenacetin, once widely used, was found to increase the risk of developing renal cell carcinoma.
- Acetaminophen, a metabolite of phenacetin, has significant carcinogenic activity in the renal pelvis.
Multiple Choice Questions
- Major risk factors for renal cell carcinoma include all of the following except:
- chronic alcohol consumption.
- chronic tobacco smoking.
- obesity.
- hypertension.
- What kidney tumor occurs primarily in children under the age of 5 years?
- Wilms’ tumor
- Renal cell carcinoma
- Transitional cell carcinoma
- Sarcoma
- Clear cell carcinomas constitute what percentage of all renal cell carcinomas?
- 55%
- 65%
- 75%
- 85%
- What gene is mutated in nearly all clear cell carcinomas of the kidney?
- BRCA1
- BRCA2
- von Hippel Lindau
- NAT2
- Which of the following analgesic drugs is carcinogenic in the renal pelvis?
- Aspirin
- Ibuprofen
- Acetaminophen
- Phenacetin
- Epidemiologic studies of kidney cancer and type 2 diabetes may suffer from what type of bias?
- Reverse causality bias
- Differential selection bias
- Berkson’s bias
- Protopathic bias
Essay Questions
- Discuss the global epidemiology of kidney cancer.
- Characterize the major histologic cell types of kidney cancer.
- Discuss trends in the mortality from kidney cancer.
- Discuss the major risk factors for renal cell carcinoma.
- Discuss the importance of mutations in the von Hippel Lindau gene in the pathogenesis of clear cell carcinoma (the dominant histological cell type of renal cell carcinoma).
- Discuss the major risk factors for transitional cell carcinoma of the renal pelvis.
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Test Bank | Epidemiology of Chronic Disease 2e by Harris
By Randall E. Harris
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