Chapter 27 Test Bank Epidemiology Of Testicular Cancer - Test Bank | Epidemiology of Chronic Disease 2e by Harris by Randall E. Harris. DOCX document preview.
Chapter 27. Epidemiology of Testicular Cancer
TEST BANK
True & False Questions
- Based upon pathological review, about 50% of testicular germ cell tumors are seminomas, 40% are nonseminomas, and 5-10% consist of components of both cell types.
- Seminomas primarily occur in adult men but rarely in infants. These tumors do not express fetal proteins such as alpha fetoprotein, but some do express human chorionic gonadotrophin.
- Nonseminomas include embryonal carcinomas, immature (malignant) teratomas, and choriocarcinomas. These tumors do express alpha fetoprotein, and the majority are diagnosed before age 30.
- Testicular cancer accounts for only about 1% of all malignant neoplasms in males. Nevertheless, this malignancy is the most common malignancy in young men under 40 years of age.
- During 2018, 71,105 incident cases were diagnosed, and 9,507 deaths were attributed to testicular cancer in the world population.
- African American men have higher rates of testicular cancer than Caucasian American men.
- Among men living in developed nations, the incidence of testicular cancer is rising, but the mortality is falling.
- The vast majority of testicular cancer are diagnosed in elderly men.
- Testicular germ cell tumor karyotypes are characterized by aneuploidy, which means that the chromosome number is not an exact multiple of the usual haploid number (23 in humans).
- Risk factors for testicular cancer include prior history of unilateral disease, familial history, cryptorchidism (maldescended testes), infertility, infection, and congenital anomalies and germline mutations.
Multiple Choice Questions
- Seminomas of the testis can originate from what cell types?
- Sertoli cells
- Spermatocytes
- Leydig cells
- Stem cells
- All of the above are correct.
- What fraction (percent) of cases of testicular cancer are curable by early detection and appropriate chemotherapy?
- 50%
- 75%
- 85%
- 95%
- What type of infection is associated with the highest risk of developing testicular cancer?
- Mumps
- Measles
- MRSA
- HIV
- What surgical procedure offers the best protection against the development of testicular cancer in male infants with a maldescended testis (cryptorchidism)?
- Orchiopexy before 6 months of age
- Orchiopexy before puberty
- Orchiopexy just after puberty
- No surgery is necessary.
- Approximately 80% of testicular carcinomas contain which of the following chromosomal anomalies?
- Isochromosome of the short arm of chromosome 12 called i(12p)
- Translocation of the Y chromosome
- Translocation of the X chromosome
- Reciprocal translocation of chromosomes 9 and 22 (Philadelphia chromosome)
Essay Questions
- Discuss the global epidemiology of testicular cancer.
- Briefly describe characteristic molecular and pathological features of seminomas and non-seminomas of the testes.
- Describe characteristic features of yolk sac tumors, teratomas, and choriocarcinomas.
- Discuss ethnic differences and time trends in the incidence of testicular cancer.
- Discuss the association of cryptorchidism and testicular cancer and the importance of early surgical correction.
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Test Bank | Epidemiology of Chronic Disease 2e by Harris
By Randall E. Harris
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