Ch.14 Hunting For Engrams Complete Test Bank - Neurobiology Learning 3e | Test Bank Rudy by Jerry W. Rudy. DOCX document preview.
Chapter 14: Hunting for Engrams
Test Bank
Type: true-false
Title: Chapter 14 - Question 1
1. Memories are stored in the brain like items in a warehouse.
a. True
b. False
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Title: Chapter 14 - Question 2
2. The neural (physical) basis of memories are widely distributed.
a. True
b. False
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Title: Chapter 14 - Question 3
3. Karl Lashley invented the term engram?
a. True
b. False
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Title: Chapter 14 - Question 4
4. Richard Simon invented the term engram?
a. True
b. False
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Title: Chapter 14 - Question 5
5. Simon’s term ecphory is another word for engram.
a. True
b. False
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Title: Chapter 14 - Question 6
6. The term ecphory is roughly equivalent to the term retrieval.
a. True
b. False
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Title: Chapter 14 - Question 7
7. An engram is a memory.
a. True
b. False
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Title: Chapter 14 - Question 8
8. An engram is the physical basis of a memory.
a. True
b. False
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Title: Chapter 14 - Question 9
9. Hebb’s concept of a cell assembly is still generally accepted as correct.
a. True
b. False
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Title: Chapter 14 - Question 10
10. A neuronal ensemble is quite different from a cell assembly.
a. True
b. False
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Title: Chapter 14 - Question 11
11. Brain lesion techniques can be considered a starting point in the search for engrams.
a. True
b. False
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Title: Chapter 14 - Question 12
12. If a brain lesion of a particular regions disrupts memory storage or retrieval it can be concluded that this region contains engram cells.
a. True
b. False
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Title: Chapter 14 - Question 13
13. In order to conclude that a set of neurons are engrams, these neurons must be activated only by the retrieval test.
a. True
b. False
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Title: Chapter 14 - Question 14
14. In order to conclude that a set of neurons are engrams, these neurons must be active both by the learning event and by the retrieval test.
a. True
b. False
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Title: Chapter 14 - Question 15
15. If engram cells are deleted, it should have no effect on retrieval.
a. True
b. False
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Title: Chapter 14 - Question 16
16. Immediate early genes can serve as markers or tags for neuron activated by a behavioral experience.
a. True
b. False
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Title: Chapter 14 - Question 17
17. Immediate early gene markers for of neural activity do not persist long enough to serve as markers for long-term memory engram cells.
a. True
b. False
Type: true-false
Title: Chapter 14 - Question 18
18. A major advantage of the TetTag mouse is that it permits engram cells to be tagged with a fluorescent marker that can endure for many days.
a. True
b. False
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Title: Chapter 14 - Question 19
19. Regarding the TetTag mouse, if a neuron expresses the marker a time of the behavioral retrieval test then it can be concluded that it is an engram cell.
a. True
b. False
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Title: Chapter 14 - Question 20
20. An advantage of the TetTag mouse is that it permits the temporal control over when a behavioral experience can tag a cell.
a. True
b. False
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Title: Chapter 14 - Question 21
21. If following a retrieval test, a neuron expresses a marker for an immediate early gene and the fluorescent marker, it can be concluded that this neuron is an engram cell.
a. True
b. False
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Title: Chapter 14 - Question 22
22. Optogenetics provides a methodology for testing the requirement that the activation of engrams must activate the behavioral measure of the memory.
a. True
b. False
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Title: Chapter 14 - Question 23
23. All neurons activated by the learning experience will become engram cells that support the memory.
a. True
b. False
Type: true-false
Title: Chapter 14 - Question 24
24. Neurons that overexpress CREB win in the competition for becoming engram cells.
a. True
b. False
Type: true-false
Title: Chapter 14 - Question 25
25. Neurons that overexpress CREB win in the competition for becoming engram cells because when activated by the behavioral experience, CREB targets more memory genes that other cells.
a. True
b. False
Type: true-false
Title: Chapter 14 - Question 26
26. Neurons that overexpress CREB win in the competition for becoming engram cells because their intrinsic excitability is increased.
a. True
b. False
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Title: Chapter 14 - Question 27
27. If engram cells are inhibited at the time of retrieval, the test performance will be impaired.
a. True
b. False
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Title: Chapter 14 - Question 28
28. Neuronal subensembles activated by the learning experience but not replayed during sleep will become engram assembles.
a. True
b. False
Type: essay/short answer question
Title: Chapter 14 - Question 29
29. What is an engram?
Type: essay/short answer question
Title: Chapter 14 - Question 30
30. What does it mean to say “An engram has the potential for ecphory”?
Type: essay/short answer question
Title: Chapter 14 - Question 31
31. Briefly describe Hebb’s concept of a cell assembly.
Type: essay/short answer question
Title: Chapter 14 - Question 32
32. Why must a neuron be active both the learning experience and the retrieval test to be considered an engram cell?
Type: essay/short answer question
Title: Chapter 14 - Question 33
33. What should happen during the retrieval test if engram cells are inhibited?
Type: essay/short answer question
Title: Chapter 14 - Question 34
34. What is the value of immediate early gene markers to the pursuit of engram cells?
Type: essay/short answer question
Title: Chapter 14 - Question 35
35. How was the TetTag mouse an improvement over Guzowski’s immediate gene methodology?
Type: essay/short answer question
Title: Chapter 14 - Question 36
36. What would be your conclusion if there was no overlap in the cells tagged by the training experience and those labeled by the retrieval test?
Type: essay/short answer question
Title: Chapter 14 - Question 37
37. How was Mayford able to temporally control when neurons in the TetTag mouse could be labeled with the fluorescent tag?
Type: essay/short answer question
Title: Chapter 14 - Question 38
38. Why does the optogenetics method require the use of a viral vector system?
Type: essay/short answer question
Title: Chapter 14 - Question 39
39. In the optogenetics experiment, what was the role of DOX?
Type: essay/short answer question
Title: Chapter 14 - Question 40
40. In the optogenetics experiment, what was the role of the blue light?
Type: essay/short answer question
Title: Chapter 14 - Question 41
41. The study of neural dynamics by Inokuci’s group (Gandour et al.) revealed several important discoveries. Describe two.
Type: essay/short answer question
Title: Chapter 14 - Question 42
42. What is the role of CREB in determining what neurons are selected to become engram cells?
Type: essay/short answer question
Title: Chapter 14 - Question 43
43. How did Josselyn demonstrate that neurons that overexpress CREB became engram cells?